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. 2021 Apr 13;13(8):1846. doi: 10.3390/cancers13081846

Table 2.

Detailed description of the 5 biggest cohorts (study and patient characteristics). Controlled Oral Word Association Test (COWAT); female (F), male (M); not acknowledged (n.a.); Rivermead Behavioral Memory Test (RBMT); standard deviation (SD); Trail making Test (TMT); years (y).

Author, Year, Design Sample Size (n) Gender Mean Age (y ± SD, Range) Mean Education (y ± SD or Level) Location Assessment Measurement Tools Cognition Dimensions Tested Difference Between Pre- and Post-Op or Against Control Group Follow-Up (y)
Van Lonkhuizen, 2019, prospective 242 168 F & 74 M 57.2 (23–82) 5th level 101 Left and 113 Right; 142 Frontal and 100 Non-frontal Central Nervous System Vital Signs tests Verbal and visual memory, reaction time, complex attention, and cognitive flexibility

  • Worsening of SCF, anxiety and depression before and at 1y (p < 0.01) with surgery

  • No difference after surgery

 1
Rijnen, 2019, prospective 261 189 F & 72 M 57.8 ± 11.7 (23–82) 14.0 ± 3.7 106 Left, 124 Right and 31 Bilateral; 154 Frontal and 107 Non-frontal Central Nervous System Vital Signs tests Verbal and visual memory, reaction time, complex attention and cognitive flexibility

  • Worsening of verbal memory, visual memory, processing speed, psychomotor speed, reaction time, attention complex and cognitive flexibility with surgery (p < 0.05)

 1
Pranckevičienė, 2019, prospective 93 68 F & 25 M 63.8 +/- 10.7 n.a 36 Left, 37 Right, and 20 Bilateral HVLT-R, EORTC, QLQ-30 and QLQ-BN20 Verbal, working and visual memory and complex attention

  • Worsening of working memory, delayed recall and recognition, flatter learning slope and less effective acquisition compared to control group

 n.a
van der Vossen, 2014, retrospective 136 106 F & 30 M 59.1 ± 12.7 n.a 66 Convexity and 70 Non-convexity CFQ and HADS Cognitive flexibility, anxiety, and depression

  • Worsening of cognitive and/or emotional problems in 40% of patients with surgery

 3.0 ± 0.9
Krupp, 2009, retrospective 91 60 F & 31 M 56 ± 10 (31–75) n.a 48 Left and 43 Right; 40 Frontal and 51 Non-frontal Others Language and cognitive flexibility

  • Worsening of concentration performance, verbal knowledge, technical ability, and word fluency compared to control group

 1.25 ± 0.3