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. 2021 Apr 13;13(4):544. doi: 10.3390/pharmaceutics13040544

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of DOPC and cholesterol on hepatic knockdown efficiency (3 mice/group). The siRNA against factor VII (siFVII) was encapsulated in LNP_ssPalmO-Phe at the indicated lipid composition. All of the LNP_ssPalmO-Phe constructs contained an additional 3% of 1-(monomethoxy polyethyleneglycol2000)2,3-dimyristoylglycerol (DMG-PEG2000). Mice were injected with LNP_ssPalmO-Phe in the tail vein; the dose was 0.02 mg/kg siRNA. The serum concentration of FVII was quantified 24 h after injection. The relative serum concentration was normalized to the PBS group. Statistical analysis was performed by one-way ANOVA followed by Tukey–Kramer test; *: p < 0.05 against 70/0/30, **: p < 0.01 against 70/0/30, ^#: p < 0.05 against 62.5/7.5/30.