Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 13;13(4):544. doi: 10.3390/pharmaceutics13040544

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Hemolytic activity in the presence of serum proteins. Hemolytic activity at pH 5.5 was evaluated using LNP_ssPalmO-Phe (filled symbols) or LNP containing DLin-MC3-DMA (LNP_MC3 (open symbols). The lipid composition was adjusted to the previous literature values (ionizable lipids/DSPC/Chol/PEG = 50/10/38.5/1.5) [24,25]. Hemolytic activity was assessed in the presence of (a) 10 μg, (b) 30 μg and (c) 60 μg of serum proteins, respectively. Hemolytic activity in the absence of serum proteins as a control is shown in all charts.