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Particle properties of the siRNA-encapsulating LNPs with different ssPalm (as shown in Figure 5).
| Lipid | Size (nm) | PdI | Zeta-Potential (mV) | siRNA Recovery | siRNA Encapsulation |
|---|---|---|---|---|---|
| ssPalmO-Phe | 96 | 0.079 | −6.0 | 46% | 100% |
| ssPalmO-Ben | 98 | 0.069 | −6.5 | 51% | 99% |
| ssPalmO-P4C2 | 98 | 0.099 | −7.0 | 21% | 100% |
| ssPalmE-P4C2 | 104 | 0.057 | −6.3 | 60% | 100% |
