Table 3.
Statistical analyses’ results: contribution of bacterial genera to the principal components extracted from the matrix with relative abundance in feces of females with gallstone disease before CCE (percentage of total variance in brackets) and p-values for multiple regression with blood biochemistry (coefficients of determination in brackets).
| Genera: PCA 1 | ||||
| Main | PC 1 | PC 2 | PC 5 | PC 6 |
| contributors | (35%) | (21%) | (5%) | (5%) |
| Prevotella | 0.102 [0.41] 3 | 0.79 [−0.90] | 0.00 | 0.00 |
| Enterococcus | 0.84 [−0.97] | 0.07 [0.22] | 0.01 | 0.00 |
| Faecalibacterium | 0.02 | 0.00 | 0.17 [−0.37] | 0.02 |
| Blautia | 0.00 | 0.03 | 0.01 | 0.21 [0.50] |
| Bifidobacterium | 0.01 | 0.04 | 0.30 [−0.49] | 0.00 |
| Gemmiger | 0.00 | 0.02 | 0.15 [0.45] | 0.00 |
| Ruminococcus | 0.00 | 0.01 | 0.01 | 0.07 [−0.39] |
| un. Ruminococcaceae | 0.00 | 0.01 | 0.01 | 0.21 [−0.57] |
| Genera: Multiple regression | ||||
| R/R2 | 0.72/0.51 | 0.56/0.32 | 0.64/0.41 | 0.71/0.50 |
| Age | 0.16 | 0.92 | 0.13 | 0.12 |
| BMI | 0.29 | 0.72 | 0.09 3 | 0.42 |
| Glucose | 0.71 | 0.25 | 0.03 4 | 0.76 |
| ALT | 0.55 | 0.22 | 0.12 | 0.03 |
| AST | 0.73 | 0.48 | 0.10 | 0.03 |
| Bilirubin | 0.04 | 0.55 | 0.17 | 0.04 |
1 PCA stands for principle component analysis (based on covariance). Only those principal components that (a) account for the bigger fraction of the total data variance and/or (b) displayed a statistically significant correlation with patients’ characteristics are shown. 2 The values in bold show the two topmost contributions. 3 Factor loadings for variables (taxon relative abundance) are given in square brackets. 4 The values in bold italics and underlined italics are at p ≤ 0.05 and p ≤ 0.10, respectively.