Figure 1.

Exosomal proteomes obtained for the distinct biofluids. Steps implemented to obtain the final proteomes using the three databases (Vesiclepedia, ExoCarta, EVpedia) for cerebrospinal fluid (CSF), serum and plasma. A set of exclusion filters was used in this order: number of entries for the biofluid, number of ID entries for Homo sapiens, number of ID entries for H. sapiens and exosomes, number ID entries for H. sapiens and exosomal gene names, number of corresponding PubMed articles, number of gene names and number of gene names without repetitions. Subsequently, the lists obtained for the three databases were overlapped, the repetitions deleted and, the gene names corresponding to the exosomal proteins identified in the literature for CSF, serum or plasma were included in the final lists. The EVpedia’s obtained Uniprot IDs were converted to gene names. In the case of CSF, only EVpedia had information available. * One study was excluded since it was related to urine exosomal proteome and not to serum.