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. 2021 Apr 11;22(8):3933. doi: 10.3390/ijms22083933

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Characterization of the exosomal proteome from distinct biofluids. Exosomal proteomes associated molecular functions (a), biological processes (b) and pathways (c) analysis. Gene ontology (GO) analysis was performed for gene lists corresponding to the exosomal proteomes from serum, plasma and CSF, through the Panther classification system. Exclusive GO terms for exosomes isolated from only one biofluid or shared only by exosomes from two biofluids were represented below the dashed lines. Abbreviations of molecular function GOs terms: GO:0005488 binding; GO:0003824 catalytic activity; GO:0005198 structural molecule activity; GO:0098772 molecular function regulator; GO:0005215 transporter activity; GO:0060089 molecular transducer activity; GO:0140110 transcription regulator activity; GO:0045182 translation regulator activity; GO:0038024 cargo receptor activity. Abbreviations of biological process GOs terms: GO:0009987 cellular process; GO:0008152 metabolic process; GO:0065007 biological regulation; GO:0051179 localization; GO:0050896 response to stimulus; GO:0032501 multicellular organismal process; GO:0002376 immune system process; GO:0022610 biological adhesion; GO:0032502 developmental process; GO:0071840 cellular component organization or biogenesis; GO:0000003 reproduction; GO:0008283 cell proliferation; GO:0044848 biological phase; GO:0043473 pigmentation; GO:0048511 rhythmic process. Abbreviations of pathways GOs terms: P00034 integrin signaling pathway; P00031 inflammation mediated by chemokine and cytokine signaling pathway; P00049 Parkinson disease; P00011 blood coagulation; P06664 gonadotropin-releasing hormone receptor pathway; P00029 Huntington disease; P00016 cytoskeletal regulation by Rho GTPase; P00057 Wnt signaling pathway; P06959 CCKR signaling map; P00021 FGF signaling pathway; P00012 cadherin signaling pathway; P00018 EGF receptor signaling pathway; P00044 nicotinic acetylcholine receptor signaling pathway; P00004 Alzheimer’s disease-presenilin pathway; P00053 T cell activation; P00006 apoptosis signaling pathway; P00026 heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; P00005 angiogenesis; P00003 Alzheimer’s disease-amyloid secretase pathway; P00047 PDGF signaling pathway. Exo, Exosomes.

Characterization of the exosomal proteome from distinct biofluids. Exosomal proteomes associated molecular functions (a), biological processes (b) and pathways (c) analysis. Gene ontology (GO) analysis was performed for gene lists corresponding to the exosomal proteomes from serum, plasma and CSF, through the Panther classification system. Exclusive GO terms for exosomes isolated from only one biofluid or shared only by exosomes from two biofluids were represented below the dashed lines. Abbreviations of molecular function GOs terms: GO:0005488 binding; GO:0003824 catalytic activity; GO:0005198 structural molecule activity; GO:0098772 molecular function regulator; GO:0005215 transporter activity; GO:0060089 molecular transducer activity; GO:0140110 transcription regulator activity; GO:0045182 translation regulator activity; GO:0038024 cargo receptor activity. Abbreviations of biological process GOs terms: GO:0009987 cellular process; GO:0008152 metabolic process; GO:0065007 biological regulation; GO:0051179 localization; GO:0050896 response to stimulus; GO:0032501 multicellular organismal process; GO:0002376 immune system process; GO:0022610 biological adhesion; GO:0032502 developmental process; GO:0071840 cellular component organization or biogenesis; GO:0000003 reproduction; GO:0008283 cell proliferation; GO:0044848 biological phase; GO:0043473 pigmentation; GO:0048511 rhythmic process. Abbreviations of pathways GOs terms: P00034 integrin signaling pathway; P00031 inflammation mediated by chemokine and cytokine signaling pathway; P00049 Parkinson disease; P00011 blood coagulation; P06664 gonadotropin-releasing hormone receptor pathway; P00029 Huntington disease; P00016 cytoskeletal regulation by Rho GTPase; P00057 Wnt signaling pathway; P06959 CCKR signaling map; P00021 FGF signaling pathway; P00012 cadherin signaling pathway; P00018 EGF receptor signaling pathway; P00044 nicotinic acetylcholine receptor signaling pathway; P00004 Alzheimer’s disease-presenilin pathway; P00053 T cell activation; P00006 apoptosis signaling pathway; P00026 heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway; P00005 angiogenesis; P00003 Alzheimer’s disease-amyloid secretase pathway; P00047 PDGF signaling pathway. Exo, Exosomes.