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. 2021 Apr 11;22(8):3933. doi: 10.3390/ijms22083933

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GO analysis of the shared exosomal proteome. Shared exosomal proteome associated molecular functions (a), biological processes (b) and pathways (c). GO analysis was performed for gene lists corresponding to the exosomal proteomes from serum, plasma and CSF, through the Panther classification system. Abbreviations of molecular function GOs terms: GO:0005488 binding; GO:0003824 catalytic activity; GO:0098772 molecular function regulator; GO:0005198 structural molecule activity; GO:0060089 molecular transducer activity; GO:0005215 transporter activity; GO:0140110 transcription regulator activity. Abbreviations of biological process GOs terms: GO:0009987 cellular process; GO:0008152 metabolic process; GO:0050896 response to stimulus; GO:0002376 immune system process; GO:0065007 biological regulation; GO:0051179 localization; GO:0032501 multicellular organismal process; GO:0022610 biological adhesion; GO:0032502 developmental process; GO:0000003 reproduction. Abbreviations of pathways GOs terms: P00011 blood coagulation; P00016 cytoskeletal regulation by Rho GTPase; P00034 integrin signaling pathway; P00029 Huntington disease; P00049 Parkinson disease; P00050 plasminogen activating cascade; P00044 nicotinic acetylcholine receptor signaling pathway; P00031 inflammation mediated by chemokine and cytokine signaling pathway; P00024 glycolysis; P00006 apoptosis signaling pathway; P06664 gonadotropin-releasing hormone receptor pathway; P06959 Cholecystokinin receptor (CCKR) signaling map; P00004 Alzheimer’s disease-presenilin pathway; P00057 Wnt signaling pathway; P00005 angiogenesis.