Figure 5.

Gelsolin levels in dementia and AD determined by Western blot analysis. Immunoblot analysis of gelsolin in serum-derived exosomes from controls (CDR = 0 and MMSE–) and individuals with dementia (CDR ≥ 1 and MMSE+) from University of Aveiro (UA)-dementia group (a), including AD clinically diagnosed cases and controls (UA- and University Medical Center Goettingen (UMG)-groups) (b). ROC curves were obtained for the control and dementia group (UA-dementia group) (c) and controls and AD cases from UA and UMG (d). Each point represents the densitometry ratio obtained for each individual and the solid horizontal line shows median. Abbreviations: AD, Alzheimer’s disease; A.U., arbitrary units; AUC, area under the curve; C, controls; CDR, clinical dementia rating; MMSE, Mini-Mental State Examination; ROC, receiver operating curve. ** p ≤ 0.01, * p ≤ 0.05.