Figure 6.

Gelsolin concentrations in dementia and AD cases determined by ELISA. Gelsolin levels were assessed through ELISA assays in serum-derived exosomes from controls (CDR = 0 and MMSE–) and individuals with dementia (CDR ≥ 1 and MMSE+) from UA-dementia group (a), and from AD clinically diagnosed cases and controls from UA- and UMG-groups (b). ROC curves were obtained for the control and dementia group (UA-dementia group) (c) and controls and AD cases from UA- and UMG-groups (d). Each point represents the gelsolin mean concentration obtained for each individual and the solid horizontal line shows median of the groups. Abbreviations: AD, Alzheimer’s disease; A.U., arbitrary units; AUC, area under the curve; C, controls; CDR, clinical dementia rating; ELISA, enzyme-linked immunosorbent assay, MMSE, Mini-Mental State Examination; ROC, receiver operating curve. ** p ≤ 0.01.