Table 3.
Mediation analysis with Placental abnormalities as mediator.
| Fertility Group | Total Effect | Direct Effect | Indirect Effect | %Mediation | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LPTB | EPTB | LPTB | EPTB | LPTB | EPTB | LPTB | EPTB | |||||||
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |||
| Fertile | ref | ref | ref | ref | ref | ref | ||||||||
| ART | ||||||||||||||
| All ART | 1.47 | 1.37–1.58 ‡ | 1.72 | 1.52–1.93 ‡ | 1.36 | 1.26–1.46 ‡ | 1.45 | 1.28–1.62 ‡ | 1.08 | 1.07–1.09 ‡ | 1.19 | 1.15–1.22 ‡ | 23.27 ‡ | 37.27 ‡ |
| Fresh | 1.48 | 1.36–1.60 ‡ | 1.71 | 1.48–1.94 ‡ | 1.38 | 1.26–1.49 ‡ | 1.44 | 1.25–1.62 ‡ | 1.08 | 1.06–1.09 ‡ | 1.19 | 1.16–1.23 ‡ | 21.83 ‡ | 38.87 ‡ |
| Frozen | 1.41 | 1.21–1.62 ‡ | 1.61 | 1.24–1.98 ‡ | 1.31 | 1.12–1.49 ‡ | 1.39 | 1.08–1.70 ‡ | 1.08 | 1.06–1.10 ‡ | 1.16 | 1.10–1.21 ‡ | 25.36 ‡ | 35.91 ‡ |
| Autologous egg | 1.45 | 1.34–1.56 ‡ | 1.69 | 1.48–1.89 ‡ | 1.34 | 1.24–1.44 ‡ | 1.42 | 1.25–1.60 ‡ | 1.08 | 1.07–1.09 ‡ | 1.19 | 1.15–1.22 ‡ | 24.02 ‡ | 38.39 ‡ |
| Donor egg | 1.69 | 1.32–2.06 ‡ | 1.74 | 1.13–2.34 ‡ | 1.58 | 1.23–1.92 ‡ | 1.48 | 0.97–1.98 ‡ | 1.07 | 1.04–1.10 ‡ | 1.18 | 1.09–1.26 ‡ | 15.99 ‡ | 35.15 ‡ |
| ICSI | 1.48 | 1.32–1.65 ‡ | 1.61 | 1.31–1.91 ‡ | 1.39 | 1.23–1.55 ‡ | 1.34 | 1.09–1.59 ‡ | 1.07 | 1.05–1.08 ‡ | 1.20 | 1.15–1.25 ‡ | 19.45 ‡ | 44.40 ‡ |
| No ICSI | 1.46 | 1.30–1.62 ‡ | 1.74 | 1.44–2.04 ‡ | 1.35 | 1.21–1.49 ‡ | 1.46 | 1.21–1.71 ‡ | 1.08 | 1.06–1.10 ‡ | 1.19 | 1.15–1.24 ‡ | 23.83 ‡ | 37.75 ‡ |
LPTB = Late preterm birth; EPTB = Early preterm birth; OR = odds ratio; 95% CI = 95% confidence interval; ‡ = significant at p < 0.001.