Figure 3.

Dietary sodium restriction does not modulate cardiac systolic function in mice with DCM. (A–D) Age-related changes in left ventricular systolic function measured as ejection fraction (EF; A), fractional shortening (FS; B), cardiac output (CO; C), and left ventricle mass (LV mass; D). DCM mice on LSD (closed symbol) or NSD (open symbol) (enrollment n = 11–14 per group), and WT mice (dashed line, n = 8–10). Data are presented as mean ± standard error of the mean (SEM). **** p < 0.0001, * p < 0.05 (DCM vs. WT) as determined by two-way ANOVA with Bonferroni multiple comparison test.