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. 2021 Apr 14;22(8):4035. doi: 10.3390/ijms22084035

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dietary sodium restriction activates classical and non-classical renin-angiotensin-aldosterone system (RAAS) in mice with DCM. (A–D) Effect of dietary sodium restriction on plasma levels of the classical RAAS: (A) renin activity (AU, arbitrary units), (B) angiotensin II (AngII), (C) aldosterone, and counter-regulatory RAAS: (D) angiotensin converting enzyme 2 (ACE2) and (E) angiotensin (1–7) (Ang (1–7)). Number of DCM mice n = 7–8 per group. WT control mice (dashed line, n = 5–8) at 17 weeks of age. Data are presented as mean ± SEM. **** p < 0.0001, *** p < 0.001, * p < 0.001 (DCM vs. WT); ⁺⁺⁺⁺ p < 0.0001, ⁺⁺ p < 0.01, ⁺ p < 0.05 (DCM on NSD vs. DCM on LSD) by one-way ANOVA with Newman-Keuls multiple comparison test.