Table 1.

Inhibitory constant (Ki) of human cystatins for human target proteases.

	Legumain	Cathepsin V	Cathepsin L
Cystatin M/E		Ki (nM) *
Wild-type	0.25 (0.0016)	0.47	1.78
N39A mutant	>100	0.34	1.77
W106A mutant	0.72	>100	11.7
Cystatin C	7.28 (0.2)	0.02	0.08
Cystatin D	>100 (>1000)	29.6	2.81
Cystatin F	>100 (10)	>100	0.49
Cystatin S	>100	>100	>100
Stefin A	>100 (>1000)	0.11	0.05
Stefin B	>100 (>1000)	0.13	0.05

For the sake of homogeneity with the body text, cystatin C numbering is used. * From [35]. In bracket: pig legumain [10].