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. 2021 Apr 14;14(4):362. doi: 10.3390/ph14040362

Figure 6.

Figure 6

Kim et al.’s 3D cell printing of in vitro stabilised skin model and in vivo prevascularised skin patch using tissue-specific extracellular matrix bioink. (a) Development of decellularised extra cellular matrix bioink. (b) Representative photographs during 21 days of wound healing. (c) Variations of wounds gaps. (d) Re-epithelialisation values in the wounds areas on various days during wound healing. Data indicate mean ± SD. * p < 0.05 versus Hank Balanced Salt Solution (HBSS), # p < 0.05 versus dECM-ASC (skin equivalent composed of derived extracellular matrix and containing adipose-derived mesenchymal stem cells (n = 8–11). (e) In vivo vascularisation evaluation. Representative photographs of skin wound tissues on day 7 after immunostaining with anti-CD31 (green). Image reproduced with permission from Kim et al. [115]. Copyright 2018 Elsevier.