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. 2021 Apr 14;22(8):4048. doi: 10.3390/ijms22084048

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Quantitative analysis of the mineral-to-organic matrix (M/M) ratio, carbonate substitution (C/P ratio), mineral crystallinity and collagen maturity in the femur of Pappa2^wt/wt and Pappa2^ko/ko mice at 0′, 30′, 120′ and 240′ after rmIGF-1 administration in males (A–D) and females (E–H). Data are represented as mean ± S.E.M. (n = 6–9/group). Tukey-corrected tests: ^#/##/### p < 0.05/0.01/0.001 between genotypes (same time); *^/**^/*** p < 0.05/0.01/0.001 versus 0′ (same genotype).