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. 2021 Apr 14;22(8):4049. doi: 10.3390/ijms22084049

Figure 3.

Figure 3

Depletion of Treg cells with anti-CD25 antibody (PC61) during early CAC restores tumor development in STAT6−/− mice. (A) A schematic time schedule of the PC61 antibody administration in the WT and STAT6−/− mice that received the AOM/DSS administration (CAC-induced mice). After 10 and 15 days, the groups of WT or STAT6−/− CAC-induced mice were injected i.p. with 200 µg of PC61 antibody. The CAC progression was analyzed over 77 days. (B–E) The disease activity index (DAI) (B), body weight loss (C), representative photographs of colons opened longitudinally, showing macroscopic aspects (D), and number of tumors (E) on Day 77, after the AOM/DSS administration in the WT CAC, WT PC61, STAT6−/− CAC, and STAT6−/− PC61 mice, are shown. The data are expressed as the mean ± SEM and are representative of two independent experiments, with at least five mice per group. * p < 0.05, ** p < 0.01, **** p < 0.001.