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. 2021 Apr 14;13(8):1882. doi: 10.3390/cancers13081882

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A diagram illustrating the mechanism of action of Antibody-Drug Conjugate (ADC) in a cancer cell. (A): High-affinity Antibody binds to the drug, forming ADC, entering the double lipid-membrane layer of the cell to cause cell death. (B): ADC binds to the pro-survival receptor of cancer cells, inhibiting its function, commencing apoptosis. (C): ADC binds to both the membrane-surface antigen of the cancer cell and an effector cell in the immune system, inducing cellular cytotoxicity lysing the cancer cells. The figure was created with BioRender.com (Accessed on 1 February 2021) and was exported under a paid subscription.