Figure 5.

Effect of native/uncoated or growth factor-coated vCM on the anti- (a) and pro- fibrinolytic (b) gene expression in primary hOFs. Cells were grown under each of the four experimental conditions described in Figure 3 before total RNA was extracted and analyzed by qRT-PCR for the expression of THBD, SERPINE1, THBS1, and F3 antifibrinolytic (a) as well as PLAT, PLAU, PLAUR, and MMP14 profibrinolytic (b) genes. Values normalized to GAPDH are expressed relative to the values of control cells (Ctrl) grown as described in Figure 3a. Means ± SD from three independent experiments and significant differences to the Ctrl unless otherwise indicated, *** p < 0.001, ** p < 0.01, * p < 0.05 are shown.