Table 3.

Variant Details for Likely Pathogenic and Pathogenic Variants, by Ethnicity and Ancestry

Adjudication	Ethnicity, Ancestry	Gene	HGVSc	HGVSp	Impacts
Pathogenic	Non-Hispanic, White	LMNA	NM_170707.3:c.673C>T	NP_733821.1:p.Arg225Ter	Stop Gained
		TNNT2	NM_000364.3:c.650_652delAGA NM_001001430.2:c.629_631delAGA	NP_000355.2:p.Lys217del NP_001001430.1:p.Lys210del	Inframe Deletion
		TTN	NM_001267550.1:c.61876C>T NM_133378.4:c.54172C>T	NP_001254479.1:p.Arg20626Ter NP_596869.4:p.Arg18058Ter	Stop Gained
Likely Pathogenic	Non-Hispanic, White	BAG3	NM_004281.3:c.1417C>T	NP_004272.2:p.Arg473Ter	Stop Gained
		FLNC	NM_001458.4:c.4926_4927insACGTCACA	NP_001449.3:p.Val1643ThrfsTer26	Frameshift Variant
		FLNC	NM_001458.4:c.1948C>T	NP_001449.3:p.Arg650Ter	Stop Gained
		LMNA	NM_170707.3:c.949G>A	NP_733821.1:p.Glu317Lys	Missense Variant
		RBM20	NM_001134363.1:c.1906C>T	NP_001127835.1:p.Arg636Cys	Missense Variant
		TTN	NM_001267550.1:c.90844delA NM_133378.4:c.83140delA	NP_001254479.1:p.Thr30282ArgfsTer8 NP_596869.4:p.Thr27714ArgfsTer8	Frameshift Variant
		TTN	NM_001267550.1:c.88703_88704delAC NM_133378.4:c.80999_81000delAC	NP_001254479.1:p.His29568LeufsTer7 NP_596869.4:p.His27000LeufsTer7	Frameshift Variant
		TTN	NM_001267550.1:c.66804_66807delGAAG NM_133378.4:c.59100_59103delGAAG	NP_001254479.1:p.Lys22269HisfsTer10 NP_596869.4:p.Lys19701HisfsTer10	Frameshift Variant
		TTN	NM_001267550.1:c.64915C>T NM_133378.4:c.57211C>T	NP_001254479.1:p.Arg21639Ter NP_596869.4:p.Arg19071Ter	Stop Gained
		TTN	NM_001267550.1:c.71307_71310dupTGAC NM_133378.4:c.63603_63606dupTGAC	NP_001254479.1:p.Ser23771Ter NP_596869.4:p.Ser21203Ter	Frameshift Variant
	Non-Hispanic, African Ancestry	TTN	NM_001267550.1:c.83515C>T NM_133378.4:c.75811C>T	NP_001254479.1:p.Arg27839Ter NP_596869.4:p.Arg25271Ter	Stop Gained
		TTN	NM_001267550.1:c.66931_66932delAA NM_133378.4:c.59227_59228delAA	NP_001254479.1:p.Lys22311ValfsTer3 NP_596869.4:p.Lys19743ValfsTer3	Frameshift Variant