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Schematic workflow for local therapy decision in primary localized sacral/pelvic Ewing sarcoma (EwS) and related entities based on EURO Ewing 2012 and COG AEWS1031 guidelines. The EURO Ewing 2012 recommends adjuvant radiotherapy for most sacral/pelvic tumors (dotted line). * 45 Gy if organs at risk (e.g., joints, myelon) are near the tumor. CTX, chemotherapy; CR, complete response; MRI, magnetic resonance imaging; R, resection status; RT, radiotherapy; TB, tumor board.
