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Schematic workflow for local therapy decision in thoracic/mediastinal Ewing sarcoma (EwS) and related entities based on EURO Ewing 2012 and COG AEWS1031 guidelines. Preoperative RT concepts are not included. * in case of local pleural infiltration, pleurectomy may be indicated. CTX, chemotherapy; CR, complete response; ITB, international tumor board; PR, partial response; R, resection status; RT, radiotherapy.
