Effect of L-carnitine on serum levels of ACE1, ACE2, TMPRSS2, Furin, CRP, and tumor necrosis factor-alpha (TNF-α) in humans. Serum concentrations of ACE1 (A), ACE2 (B), TMPRSS2 (C), Furin (D), ACE1/ACE2 ratio (E), CRP (F), and TNF-α (G) in L-carnitine supplemented (CAR, black bars) or placebo (PLA, gray bars) group at baseline [30], after 5 weeks of supplementation (Wk5-pre) and 48 h after an exercise challenge (Wk5 Post). A significant difference (p < 0.05) is indicated, a: different than baseline, b: different than pre-exercise, c: different than post-exercise, d: different between groups.