Table 2.
Infections described in patients with Good syndrome.
| Infection | No. of patients | Pathogens (n, %) | References |
|---|---|---|---|
| Bacterial infections | |||
| Recurrent sinopulmonary infection | 98 (30 had available culture data and 53 isolates were identified) | Haemophilus influenzae a (13, 24.5%), Pseudomonas spp. (12, 22.6%), Klebsiella spp. (7, 13.2%), Streptococcus pneumoniae (7, 13.2%), Staphylococcus aureus (4, 7.5%), Moraxella catarrhalis (2, 3.8%), Serratia sp (2, 3.8%), Streptococcus viridans group B (1, 1.9%), Salmonella sp (1, 1.9%), Enterobacter sp (1, 1.9%), Acinetobacter baumannii (1, 1.9%), Mycoplasma pneumoniae (1, 1.91%) Candida albicans (1, 1.91%) A pathogen was not isolated in 68 cases of recurrent sinusitis, bronchitis, or pneumonitis which were documented to be considered of possible infectious pathogenesis. | [1,2,5,7–10,14,15,18,19,21,25,26,27,29,31,35,37,39–42,44–46,51,52,54,57,59,65,69,73–76,78,83,85,93–95,101,104,112,114,119,123,124,128,132,133,134,138,142,145,147,148,150,154,155,157,159,166–168,171–176,181–187,189,209] |
| Other lung infections | 18 | Necrotizing pneumonia with lung abscess (1), mediastinitis (1), empyema (1), bronchiectasis (15) | [2,8–10,19,54,95,134,142, 147,148,154,175,176,181,182,184] |
| Bacteremia | 16 (13 had available culture data | No pathogen recorded (3) Campylobacter spp (5, 38.5%), H. influenzae (1, 7.7%), Klebsiella spp. (1, 7.7%), Pseudomonas spp. (1, 7.7%), group A streptococcus (1, 7.7%), Alcaligenes xylosoxidans (1, 7.7%), Salmonella spp (1, 7.7%), E. coli (1, 7.7%), Gram-negative bacteria (1, 7.7%) | [2,5,23,42,56,60,64,87,140,150,187,190] |
| Bacterial diarrhea | 7 (6 with culture data) | Salmonella spp. (3), C. jejuni (2), Clostridium difficile colitis (1), no pathogen recorded (1) | [2,18,27,42,64,86,112] |
| Urinary tract infections | 5 (2 cases with culture data) | Proteus spp. (1), E. coli (1) | [159,172–174,189] |
| Skin infections | 2 | Furunculosis and skin abscess (1), wound infection, (C. perfringens) (1) | [157,188] |
| Bone and joint infections | 2 | Osteomyelitis (Alcaligenes xylosoxidans), arthritis Mycoplasma spp. (1) | [23,86] |
| Mycobacterial infections | |||
| Tuberculosis | 2 | Pulmonary (1), pulmonary and otic (1) | [114,174] |
| Other mycobacteria | 1 | Bronchopulmonary infection with Mycobacterium malmoense | [77] |
| Viral infections | |||
| CMV disease | 25 | Retinitis (8), pneumonia (5), encephalitis (3), colitis (3), enteritis (3), adrenalitis (2), gastritis (1), | [2,5,12,20,28,36,42,44,54,58,59,64,65,113,117,138,150,175] |
| CMV infection of uncertain clinical significance | 7 | CMV infection of tumor cells (1), CMV serology without any other symptoms (1) Asymptomatic viruria (2), CMV recovered from sputum (2), CMV inclusions at autopsy in: salivary glands (1), thyroid (1), parathyroid (1), lungs (7), trachea (1), Kaposi cells (1), esophagus (1), pancreas (1) prostate (1), spleen, adrenals (2), liver (1), colon (1). | [101,113,142,150,173,175,182] |
| Varicella-zoster virus | 11 | Disseminated varicella (1), herpes zoster (10) | [20,37,64,65,75,99,113,127,144,182,189] |
| Herpes simplex virus (HSV) | 8 | Skin infections (4) Epiglottitis (1), tracheobronchitis (1) keratitis (1), recurrent genital herpes (1), ulcerative dermatitis (1, possibly related to HSV), respiratory infection (2) Disseminated HSV infection (1) | [11,16, 93,94,98,117,135,145] |
| HHV-8 | 3 | Kaposi sarcoma | [27,75,101] |
| HPV | 1 | Epidermodysplasia verruciformis | [93] |
| Echovirus 22 | 1 | Cultured from ascitic fluid | [2] |
| JC virus | 1 | Progressive multifocal leucoencephalopathy | [7] |
| Fungal infections | |||
| Candida infections | 29 | Persistent mucocutaneous candidiasis (5), oropharyngeal candidiasis (10), esophagitis (6), candidemia (3), lung infection (2), oral–intestinal candidiasis at autopsy (1), candidal pyelonephritis(1), unspecified Candida infection (5) | [1,2,14,15,22,28,37,38,41,42,44,45,59,60,64,73,75,83,96,101,105,113,117,128,133,150,186,189] |
| Pneumocystis jirovecii (carinii) | 9 | Pneumonia | [2,14,36,40,59,76,96,98,173] |
| Aspergillus | 4 | Aspergillosis (1), isolation of Aspergillus from BAL and sputum (2), Disseminated aspergillosis (1) | [1,38,96,157] |
| Parasitic infections | |||
| Giardia lamblia | 4 | Giardiasis | [41,102,113,128] |
| Babesia microtii | 1 | Babesiosis | [27] |
| Toxoplasma | 1 | Ocular toxoplasmosis | [126] |
| Other infections | |||
| Recurrent eye infections such as in 3 patients, | 3 | Recurrent scleritis, cicatrizing keratoconjuctivitis conjunctivitis | [30,112,172] |
| Genital infections | 2 | Orchitis (1), penile infections (1) | [45,172] |
| Lymphadenitis | 1 | Cervical lymph nodes (1) | [189] |
a
Numbers in parenthesis represent % of total isolates (48 bacterial isolates for respiratory infections).