Table 1.
Demographic and genetic characteristics of drusenoid pigment epithelial detachment and three subtypes of exudative age-related macular degeneration.
| DPED (n = 76) | tAMD (n = 328) | PCV (n = 476) | RAP (n = 57) | |
|---|---|---|---|---|
| Mean age (years) | 77.2 ± 7.0 | 76.6 ± 8.7 | 73.3 ± 8.2 | 82.5 ± 6.5 |
| p-value (vs. DPED) | 0.97 | 4.3 × 10−4 | 2.3 × 10−5 | |
| Gender: Male | 42 (55.3%) | 227 (69.2%) | 359 (75.4%) | 23 (40.4%) |
| p-value (vs. DPED) | 0.02 | 0.0003 | 0.09 | |
| Presence of RPD | 17 (22.4%) | 65 (19.8%) | 9 (1.9%) | 34 (60.0%) |
| p-value (vs. DPED) | 0.62 | 5.1 × 10−15 | 1.2 × 10−5 | |
| DPED (n = 64) | tAMD (n = 328) | PCV (n = 476) | RAP (n = 57) | |
|
ARMS2 A69S(c.205G > T) (rs10490924)) |
||||
| TT | 38 (59.4%) | 152 (46.3%) | 160 (33.6%) | 39 (68.4%) |
| TG | 23 (36.0%) | 126 (38.4%) | 223 (46.8%) | 16 (28.1%) |
| GG | 3 (4.6%) | 50 (15.3%) | 93 (19.6%) | 2 (3.5%) |
| T-allele frequency | 0.77 | 0.66 | 0.57 | 0.82 |
| p-value (vs. DPED) | 9.2 × 10−3 | 7.2 × 10−5 | 0.32 | |
|
CFH I62V(c.184G > A) (rs800292) |
||||
| GG | 48 (75.0%) | 179 (54.6%) | 259 (54.4%) | 35 (61.4%) |
| GA | 15 (23.4%) | 122 (37.2%) | 176 (37.0%) | 20 (35.1%) |
| AA | 1 (1.6%) | 27 (8.2%) | 41 (8.6%) | 2 (3.5%) |
| G-allele frequency | 0.87 | 0.73 | 0.73 | 0.79 |
| p-value (vs. DPED) | 0.0011 | 0.008 | 0.11 |
AMD: age-related macular degeneration; DPED: drusenoid pigment epithelial detachment; PCV: polypoidal choroidal vasculopathy; RAP: retinal angiomatous proliferation; RPD: reticular pseudodrusen.