Table 2.
Comparison of demographic and genetic characteristics between drusenoid pigment epithelial detachment with or without reticular pseudodrusen.
| RPD(+) (n = 17) | RPD(−) (n = 59) | p-Value | |
|---|---|---|---|
| Mean age (years) | 77.65 ± 7.47 | 77.19 ± 6.96 | 0.78 |
| Gender: Male | 8 (47.1%) | 34 (57.6%) | 0.44 |
| Baseline VA (LogMAR) | 0.11 ± 0.22 | 0.082 ± 0.16 | 0.80 |
| Presence of MNV in the contralateral eye | 14 (82.4%) | 37 (62.7%) | 0.11 |
| DPED height (µm) | 151.12 ± 52.44 | 227.24 ± 142.49 | 0.028 |
| DPED width (µm) | 1339.77 ± 1182.09 | 1718.05 ± 1094.18 | 0.12 |
| RPD(+) (n = 16) | RPD(−) (n = 48) | p-Value | |
|
ARMS2 A69S(c.205G > T) (rs10490924) |
|||
| TT | 12 (75.0%) | 26 (54.2%) | |
| TG | 4 (25.0%) | 19 (39.6%) | |
| GG | 0 (0.0%) | 3 (6.2%) | |
| T-allele frequency | 0.88 | 0.74 | 0.11 |
|
CFH I62V (c.184G > A) (rs800292) |
|||
| GG | 12 (75.0%) | 36 (75.0%) | |
| GA | 3 (18.8%) | 12 (25.0%) | |
| AA | 1 (6.2%) | 0 (0.0%) | |
| G-allele frequency | 0.84 | 0.88 | 0.65 |
DPED: drusenoid pigment epithelial detachment; MNV: macular neovascularization; RPD: reticular pseudodrusen.