Table 3.

Therapeutic and toxicological properties for potential autophagy-related drugs against SARSCoV-2 infection according to the PubChem database [279].

Drug	Therapeutic Properties	Toxicological Properties	Compound ID (CID)
Chloroquine/hydroxycloroquine	Malaria and amebiasis treatment and prevention; Rheumatic diseases (i.e., systemic lupus erythematosus and rheumatoid arthritis) treatment.	Corneal deposits, posterior subcapsular lens opacity, ciliary body dysfunction, retinopathy and cardiac rate changes.	2719 3652
Azithromicin	Mild-to-moderate Gram positive (i.e., staphylococci) and Gram negative (i.e., Mycoplasma pneumonia) bacterial infections treatment; Protozoan infections (i.e., Toxoplasma gondii and T. cryptosporidia ) treatment.	Hepatotoxicity, nephrotoxicity and severe cutaneous reactions (i.e., erythema multiforme and toxic epidermal necrosis).	447043
Artemisinin	Leishmaniasis and Malaria treatment.	Sedative in rodent models but no significant toxicity has been reported in humans; Cardiotoxicity and QT interval prolongation	68827
Tetrandrine	Adjunctive therapy to chemotherapy in various cancer types with multiple drug resistance; Antiviral activity against Ebola virus; Anti-inflammatory and antifibrogenic actions in lung silicosis, liver cirrhosis, and rheumatoid arthritis.	Local pain, phlebitis and tissue irritation; Mild and transient hearing loss, peripheral neuropathy, cerebellar toxicity and cardiotoxicity.	73078
Imatinib	Treatment of chronic myeloid leukemia, lymphoblastic leukemia, myelodysplastic/myeloproliferative diseases, aggressive systemic mastocytosis, hypereosinophilic syndrome and/or chronic eosinophilic leukemia, dermatofibrosarcoma protuberans and malignant gastrointestinal stromal tumors.	Edema, nausea, vomiting, muscle cramps, musculoskeletal pain, diarrhea, rash, fatigue and abdominal pain.	5291
Camostat mesylate	Chronic pancreatitis.	N/A	5284360
Lopinavir/ritonavir	Antiretroviral activity against Human Immunodeficiency Virus-1 (HIV-1).	Atrioventricular block, cardiomyopathy, lactic acidosis, and acute renal failure.	11979606
Umifenovir	Broad-spectrum antiviral against influenza and other respiratory viral infections, Flavivirus, Zika virus, foot-and-mouth disease, Lassa virus, Ebola virus and herpes simplex.	Chronic administration of doses 10–50 times higher than the therapeutic human dose resulted in no pathological changes to animal subjects.	131411
Teicoplanin	Antibiotic against pseudomembranous colitis and Clostridium difficile.	Change in auditory acuity and ototoxicity.	133065662
Rapamycin	Potent immunosuppressant with both antifungal and antineoplastic properties.	Peripheral edema, hypercholesterolemia, abdominal pain, headache, nausea, diarrhea, chest pain, stomatitis, nasopharyngitis, acne, upper respiratory tract infection, dizziness and myalgia.	5284616
Heparin	Anticoagulant; Antitumoral agent with angiogenesis inhibiting properties.	Heparin-induced thrombocytopenia, which may progress to arterial thrombosis, gangrene, stroke, myocardial infarction; Spontaneous fractures and osteoporosis.	772
Dexamethasone (glucocorticoid)	Anti-inflammatory and immunosuppressive agent for a number of endocrines, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous and other conditions.	Chronic high doses of glucocorticoids can lead to the development of cataract, glaucoma, hypertension, water retention, hyperlipidemia, peptic ulcer, pancreatitis, myopathy, osteoporosis, mood changes, psychosis, dermal atrophy, allergy, acne, hypertrichosis, immune suppression, decreased resistance to infection, moon face, hyperglycemia, hypocalcemia, hypophosphatemia, metabolic acidosis, growth suppression and secondary adrenal insufficiency.	5743
Losartan	Antihypertensive able to reduce the risk of stroke in patients.	Hypotension, tachycardia, or bradycardia due to vagal stimulation.	3961
Cannabidiol	Analgesic, anticonvulsant, muscle relaxant, anxiolytic and antipsychotic agent; Treatment of rare forms of refractory epilepsy syndromes.	Sedation, somnolence and fatigue; Drug-drug interactions and hepatic abnormalities.	644019