Table 1.
Physiological parameters of wild-type (WT) and diabetic mice (db/db) at 10 and 12 months old. Blood glucose level is much higher in diabetic mice than in WT mice, as expected. Both body weight and kidney/body weight ratio are higher in diabetic mice than in WT mice. Albumin/Creatinine ratio is higher in diabetic mice compared with WT mice. Diabetic mice have more proteinuria compared with WT mice at both 10- and 12-months-old. A significant difference from WT mice is indicated by * p < 0.01.
WT 10 Months |
Dbdb 10 Months |
WT 12 Months |
Dbdb 12 Months |
|
---|---|---|---|---|
Body weight (g) | 30.64 ± 7.0 | 36.19 ± 6.5 | 30.11 ± 2.6 | 37.03 ± 6.9 |
Kidney/body weight (g/g) | 0.926 ± 0.2 | 1.0 ± 0.2 * | 0.96 ± 0.2 | 1.12 ± 0.2 * |
Glucose levels (mg/dL) | 119.4 ± 22.9 | 379.5 ± 65.5 * | 90.8 ± 18.6 | 391.0 ± 90.9 * |
Albumin/Creatinine ratio (μg/mg) | 109.8 ± 20.6 | 530.6 ± 109 * | 117.5 ± 19.7 | 650.4 ± 187 * |
Proteinurea (mg/24h) | 21.75 ± 8.0 | 35.44 ± 12.3 * | 26.36 ± 6.7 | 42.58 ± 7.6 * |