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MicroRNAs involved in aromatase regulation in breast cancer. (A) Role of Lethal-7f downregulating CYP19A1 mRNA levels in breast cancer patients. (B) Role of MIR125B1 in upregulating aromatase level by activating Akt/PI3K/mTOR pathway, contributing to chemoresistance and increasing tumor proliferation. (C) Role of MIR27B in downregulating CREB1 and NR5A2 mRNA, upregulating aromatase level and cholesterol biosynthesis in breast cancer patients.
