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. 2021 Apr 15;22(8):4072. doi: 10.3390/ijms22084072

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MicroRNAs involved in aromatase regulation in ovarian cancer. (A) Oncogenic expression of MIR224 enhances TGF-β1protein levels, inducing GC proliferation by targeting Smad4 protein, leading to a subsequent increase in the CYP19A1 mRNA levels. (B) Tumor suppressive role of MIR378 downregulates CYP19A1 mRNA levels in ovarian cancer patients. (C) Tumor suppressor role of MIR98 downregulates CYP19A1 mRNA levels in ovarian cancer patients furthermore, MIR98 was found to bind to the 3′-untranslated region of ALK4 and MMP11 mRNA induced differentiation and cell proliferation.