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Relative changes in agonist potencies, forward (kon) and reverse (koff) rate constants and calculated kinetic potencies at the S1935.42A mutant, as compared to WT D2R.
| Agonist | Potency | Relative Efficacy | koff | kon |
|---|---|---|---|---|
| DA | ↓↓↓ | − | − | ↓↓↓ |
| p-tyramine | ↑ | ↑ | − | ↑ |
| (S)-5-OH-DPAT | ↓↓ | − | ↑ | ↓↓ |
| (R)-5-OH-DPAT | ↑ | ↑↑ | ↑ | ↑ |
↑↑, strong increase; ↑, weak increase; ↓↓↓, very strong decrease; ↓↓, strong decrease.
