Figure 3.

Next-Generation Lysins. This illustration shows the basic difference in structure between the following: natural endolysins, the engineered chimeric lysin which involves the linking of the catalytic domain of one lysin to a suitable cell wall-binding domain, the Artilysin which involves the fusion of an LPS disrupting molecule to a lysin, VALs which do not possess their own cell wall-binding domain and so are fused to a suitable candidate, and truncated lysins which have the cell wall-binding domain removed to increase activity.