Figure 2.

(a) Depiction of the enzyme catalytic mechanism (black) and reversible inhibition mechanisms including competitive inhibition (blue), uncompetitive inhibition (red), and noncompetitive inhibition (both blue and red). (b) Representation of irreversible (covalent) inhibition by organophosphorus ligands and the reactivation mechanisms to revert the aged enzyme (blue) back to the inhibited complex (green). L and R represent the first and second leaving groups of the organophosphate, respectively, following the paths of inhibition and reactivation.