Scheme 2.
Reagents and solvents: (a) Epibromohydrin, K2CO3, acetone, reflux, 4 h; (b) Mesyl chloride, TEA, DCM, RT, 3 to 18 h; (c) 2,6-Difluoro-2-hydroxybenzamide, K2CO3, DMF, 80 °C, 4 to 24 h.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.