Table 2.
Inhibitory activity of compounds I, II, and V, and 1–8 against MSSA, MRSA, MDRSA 12.1, MDRSA 11.7, and MRC-5.
| Cpd | MSSA ATCC 29213 and MRSA ATCC 43300 | MRC-5 | TI | MDRSA 12.1 | MDRSA 11.7 | |
|---|---|---|---|---|---|---|
| MIC (μM) | MBC (μM) | TD90 (μM) | MIC (μM) | MIC (μM) | ||
| I | 15.6 | 249 | 49.8 | 3.2 | 24.9 | 49.8 |
| II | 14.9 | 14.9 | 226 | 15.2 | 11.9 | 11.9 |
| V | 1.4 | 1.4 | 1700 | 1231 | <2.3 | <2.3 |
| VI | 6.2 | 6.2 | >1983 | >320 | 5.0 | 9.9 |
| VII | 6.0 | 6.0 | >1916 | >320 | 4.8 | 9.6 |
| 1 | 1.2 | 1.2 | >1910 | >1591 | 1.2 | 1.2 |
| 2 | 0.6 | 0.6 | 1854 | 3090 | 0.6 | 0.6 |
| 3 | 0.5 | 0.5 | 1668 | 3034 | 1.1 | 1.1 |
| 4 | 7.1 | 7.1 | >2276 | >320 | 11.4 | 11.4 |
| 5 | 0.6 | 0.6 | 233 | 360 | 0.6 | 1.3 |
| 6 | 14.0 | 14.0 | >2238 | >160 | 11.2 | 11.2 |
| 7 | 13.3 | 13.3 | 200 | 15.0 | 5.3 | 10.7 |
| 8 | 0.25 | 0.25 | 2054 | 8200 | 0.3 | 0.3 |