Table 1.
Circulation model parameters and comparisons between model and reported hemodynamics for baseline and acutePO models
| baseline | acutePO (Δ% from Baseline) | %Change from optimized values for error > 1 SD | ||
|---|---|---|---|---|
| baseline | acutePO | |||
| Specified parameter | ||||
| HR (bpm) | 100 | 109 (+ 9%) | ||
| Fitted parameters | ||||
| SBV (ml) | 285 | 290 (+ 2%) | EDP: 5% | EDP: 3% |
| Ras (mmHg s/mL) | 1.9 | 1.9 | maxP: 7% | |
| Rcs (mmHg s/mL) | 0.2 | 1.09 (+ 145%) | maxP: 4% | |
| Tmax (kPa) | 84.0 | 84.0 | %short: 10% | |
| Matched hemodynamics | ||||
| Reported EDP (mmHg) | 11.1 ± 1.1 | 16.7 ± 0.9 | ||
| Model fit EDP (mmHg) | 11.2 | 16.7 | ||
| Reported maxP (mmHg) | 140 ± 6 | 220 ± 6 | ||
| Model fit maxP (mmHg) | 140 | 220 | ||
| Reported %short (%) | 30.0 ± 3.1 | 22.4 ± 2.2 | ||
| Model fit %short (%) | 32.0 | 20.3 | ||
Heart rate (HR) was specified based on reported values. Stressed blood volume (SBV), systemic resistance (Ras), aortic resistance (Rcs), muscle contractility (Tmax) were adjusted to match reported hemodynamic data. EDP: left ventricular end-diastolic pressure, maxP: left ventricular maximum pressure, %short: percent short-axis shortening in the anterior–posterior cavity diameter. HR and reported hemodynamics are from Sasayama et al. (1976). For each fitted parameter, the right-hand columns show the % change from the optimized value required to induce an error equal to 1 SD of the reported value (see text for more details)