In vivo study: DA inhibits tumor growth. (A) Excised tumor images from different groups of mice after 4 weeks. (B) Tumor volume with respect to time. (C) Tumor weight after 4 weeks. (D) Body weight with respect to time. (E) H&E staining of tumor and other vital organs such as heart, lungs, liver, kidney and spleen (scale bar = 100 µm). arrow marks: represent the occurrence of apoptotic cells in the B16F10 tumors from H&E staining. The data are represented as the means ± S.D. of three independent experiments * p < 0.05, ** p < 0.01, *** p < 0.001 vs. control, calculated through ANOVA prism.