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Ad-shRRM1 significantly inhibits cell viability of RRM1-expressing bladder cell lines. Cell viability was evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay after transduction with adenoviral vectors at MOI = 10 at series time point of 1, 3, 5, 7 and 9 day. (A) results in 253J cells; (B) results in RT112 cells. (MOI: multiplicity of infection; * p < 0.05, ** p < 0.005 vs. Ad-shScramble treatment).
