Table 4.
Cox proportional hazard model for all-cause mortality in patients who received RT with or without surgery for anaplastic thyroid carcinoma.
| Treatment | OP + RT ± Systemic Tx (n = 19) | RT ± Systemic Tx (n= 21) | ||||||
|---|---|---|---|---|---|---|---|---|
| Variables | Univariate Analysis | Multivariate Analysis | Univariate Analysis | Multivariate Analysis | ||||
| HR (95% CI) |
p-Value | HR (95% CI) |
p-Value | HR (95% CI) |
p-Value | HR (95% CI) |
p-Value | |
| Age (years) | 1.00 (0.93–1.09) |
0.831 | - | - | 0.98 (0.94–1.02) |
0.375 | - | - |
| Sex (male) | 1.74 (0.52–5.77) |
0.369 | - | - | 1.79 (0.60–5.39) |
0.298 | - | - |
| Size (cm) | 1.03 (0.67–1.58) |
0.893 | - | - | 1.14 (0.88–1.46) |
0.322 | - | - |
| Stage (IVC) | 2.21 (0.52–9.37) |
0.281 | - | - | 2.96 (0.95–9.22) |
0.061 | 9.37 (2.22–39.46) |
0.002 |
| Systemic Tx | - | - | - | - | 0.88 (0.34–2.25) |
0.787 | - | - |
| Cytotoxic CTx | 1.11 (0.29–4.30) |
0.883 | - | - | 1.86 (0.66–5.19) |
0.238 | - | - |
| TKI | 0.74 (0.15–3.52) |
0.702 | - | - | 0.44 (0.16–1.17) |
0.099 | 0.14 (0.04–0.51) |
0.003 |
| EQD210 (≥60 Gy) |
0.04 (0.005–0.36) |
0.004 | 0.05 (0.005–0.43) |
0.007 | 0.46 (0.10–2.04) |
0.304 | - | - |
| NLR (≥3.47) | 7.76 (1.08–55.92) |
0.042 | 2.07 (0.28–15.39) |
0.478 | 1.52 (0.59–3.90) |
0.382 | - | - |
CI, confidence interval; CTx, chemotherapy; EQD210, equivalent dose in 2-Gy fractions with an α/β ratio of 10; HR, hazard ratio; NLR, neutrophil-to-lymphocyte ratio; OP, operation; RT, radiotherapy; TKI, tyrosine kinase inhibitor; Tx, treatment.