Table 5.

Unadjusted and adjusted multivariable survival model of road exposures for recurrent wheeze by age 3 years as outcome.

Road Exposures		Unadjusted HR (95% CI)	p-Value	Adjusted HR (95% CI) *	p-Value
Birth distance to major road, meter	<100	1.53 (1.08–2.16)	0.02	1.43 (1.00–2.04)	0.05
	100–200	0.96 (0.66–1.38)	0.81	0.91 (0.63–1.31)	0.60
	201–300	0.93 (0.61–1.41)	0.74	0.95 (0.62–1.44)	0.80
	>300	Ref	---	Ref	---
Birth distance to primary road, meter	<400	0.69 (0.41–1.19)	0.19	0.72 (0.42–1.24)	0.24
	400–1000	0.91 (0.64–1.29)	0.58	0.89 (0.62–1.27)	0.51
	>1000	Ref	---	Ref	---
Pooled distance to major road, meter †	<100	1.72 (1.18–2.50)	0.004	1.59 (1.08–2.33)	0.02
	100–200	1.21 (0.84–1.76)	0.31	1.14 (0.78–1.66)	0.51
	201–300	1.04 (0.71–1.51)	0.85	1.03 (0.71–1.50)	0.88
	>300	Ref	---	Ref	---
Pooled distance to primary road, meter †	<400	0.90 (0.52–1.57)	0.72	0.92 (0.53–1.62)	0.78
	400–1000	0.91 (0.63–1.31)	0.62	0.89 (0.61–1.29)	0.53
	>1000	Ref	---	Ref	---

Abbreviations: HR = hazard ratio; CI = confidence interval; Ref = reference category. * Adjusted for age at enrollment (dichotomized by age 2 months), race/ethnicity, health insurance type, preterm birth (with cut-off at 37 months), median household income estimated by ZIP code at enrollment, parental history of asthma, population density of residential area at birth, and infant tobacco exposure at enrollment, and was stratified by sex. † Pooled estimates derived by weighting exposures according to duration spent each address up to age three or time outcome occurred, whichever happened first.