Table 2.
Top-ranked urinary biomarkers (sum-normalized) identified by MSI-CE-MS that differentiate pediatric CD (n = 18) from UC (n = 8) patients prior to induction therapy.
| m/z:RMT:Mode | Metabolite ID | Median FC | p-Value 1 | Effect Size 1 |
|---|---|---|---|---|
| 212.002:1.025:n | Indoxyl sulfate; HMDB0000682 | 2.03 | 0.00111 | 0.443 |
| 120.065:0.905:p | Threonine; HMDB0000167 | 0.51 | 0.00485 | 0.345 |
| 345.155:0.770:n | Unknown fatty acid; C16H26O8 | 1.93 | 0.00737 | 0.309 |
| 106.050:0.868:p | Serine; HMDB0000187 | 0.74 | 0.0122 | 0.273 |
| 308.099:0.791:n | Sialic acid; HMDB000230 | 1.89 | 0.0122 | 0.254 |
| 263.104:0.826:n | Phenylacetylglutamine; HMDB00006344 | 1.92 | 0.0144 | 0.261 |
| 137.046:1.039:p | Hypoxanthine; HMDB0000157 | 0.54 | 0.0144 | 0.178 |
| 222.080:0.849:p | 5-(δ-Carboxybutyl)homocysteine 2 | 0.44 | 0.0198 | 0.239 |
| 209.092:0.887:p | Kynurenine; HMDB0000684 | 0.61 | 0.0268 | 0.204 |
| 227.997:0.979:n | 5-Hydroxyindole sulfate 2 | 1.87 | 0.0357 | 0.210 |
1 Statistical significance determined by a Mann–Whitney U-test, p < 0.05 with effect size calculated using (Z2/N-1). 2 Putative identification (level 2) of unknown metabolites based on accurate mass, MS/MS, and mobility matching.