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Schematic illustration of host gene transcription modulation by HBx. Examples of HBx interactions with the host cell epigenetic machinery and their effects on host gene transcription are shown. A description of HBx/PRC2 target genes are detailed in [33]. Ac: acetylation; DNMT: DNA methyltransferases; HAT: histone acetyltransferase; HMT: histone methyltransferase; HBx: hepatitis B virus (HBV) protein x; HDAC: histone deacetylase; TF: transcription factor; Me: methylation.
