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Mean plasma concentration–time profiles following the oral co-administration of TPT with P-gp and BCRP dual inhibitor candidates to rats. (A) Benzoxanthone and xanthone derivatives and (B) coumarin derivatives. Bars represent S.D. (n = 4–6). TPT (20 mg/kg, PO) was orally administered alone or with each compound (2 mg/kg) to rats. S.D., standard deviation; PO, per oral.
