Table 1.
Composition of blank (µE1–µE5) and BVZ-loaded (µE6–µE10) microemulsions (µEs); µE6–µE7 containing 2 mg of BVZ (corresponding to 80 µL of ethyl acetate (EA)-saturated Avastin®); µE8–µE10 containing 4 mg of BVZ (corresponding to 160 µL of EA-saturated Avastin®). * The amount of s-water was 620 μL in µE6–µE7 and 540 μL in µE8–µE10 as the volume of Avastin® solution was subtracted.
| Ingredients (mg) | µE1 and 6 | µE2 and 7 | µE3 and 8 | µE4 and 9 | µE5 and 10 | |
|---|---|---|---|---|---|---|
| s-EA | 202 | 202 | 202 | 202 | 202 | |
| MICROEMULSION | Trilaurin | 60 | 60 | 60 | 60 | 60 |
| Benzyl alcohol | 75 | - | - | - | - | |
| AOT | 0.9 | 0.9 | 1.8 | 1.8 | 1.8 | |
| Epikuron®200 | 150 | 150 | 150 | 150 | 150 | |
| Taurocholic acid sodium salt | 50 | 10 | - | - | - | |
| Cremophor®RH60 | 65 | 45 | 45 | 45 | 45 | |
| Propylene glycol | - | - | 200 | 200 | 200 | |
| s-water * | 700 μL | 700 μL | 700 μL | 700 μL | 700 µL | |
| Dilution water | 5 mL | 5 mL | 3 mL | 3 mL | 3 mL | |
| HA after dilution | - | - | - | 5 | 10 |