Skip to main content
. Author manuscript; available in PMC: 2021 Apr 25.
Published in final edited form as: Chem Rev. 2017 Oct 12;118(8):4422–4447. doi: 10.1021/acs.chemrev.7b00462

Figure 6.

Figure 6.

Newly synthesized ncRNAs can be exported to the cytoplasm, uridylated and degraded by DIS3L2. (A) In mouse and human embryonic stem cells, pre-let-7 miRNA is exported to the cytoplasm and bound by LIN28, which blocks cleavage by DICER1 and recruits TUT4 and TUT7 to the pre-miRNA. After uridylation, DIS3L2 degrades the pre-miRNA183,185–188. (B) Unprocessed forms of many RNA polymerase transcripts, including pre-tRNAs and 3’ extended forms of 7SL RNA, are exported to the cytoplasm, uridylated by TUT4 and TUT7 and degraded by DIS3L264,189–191. (C) 3’ extended pre-snRNAs and pre-snoRNAs can also be exported to the cytoplasm, uridylated by TUT4 and TUT7, and degraded by DIS3L2189–191.