Figure 2.

Illustrations of some LM and EM lesions scored in the study. (a) Kimmelstiel-Wilson nodules defined as nodular mesangial sclerosis with hypocellular center (periodic acid-Schiff [PAS], original magnification ×400). (b) Glomerular epithelial hypertrophy and hyperplasia with enlarged epithelial cells forming at least 2 layers (PAS, original magnification ×400). These podocyte changes may be present in the form of podocytopathic lesions such as (c) tip lesions or (d) collapsing lesions (Jones silver, original magnification ×400, and trichrome, original magnification ×200, respectively). (e) Mean foot process width was measured by dividing the length of a segment of filtering capillary wall (yellow line) by the number of podocyte filtration slits (blue arrows) (electron micrograph, original magnification ×12,000). (f) Mesangial hyaline defined as deposits of fine, uniform, moderately electron-dense material lacking sharp edges (electron micrograph, original magnification ×6000). EM, electron microscopy; LM, light microscopy.