Table 8.
Multivariate Cox proportional hazard analysis of pathological findings predicting ESKD after adjusting for age, race, gender, duration of DM, HbA1c, and baseline UPCR
| Variables | HR | 95% CI | P value | P value for the proportionality of Cox model |
|---|---|---|---|---|
| Glomerular epithelial hyperplasia | ||||
| 0 | Ref | - | - | |
| 1 | 5.44 | 1.66–17.85 | 0.005 | 0.29 |
| Interstitial fibrosis (%) | 0.7 | |||
| 0–25 | Ref | - | 0.003 | |
| 25–50 | 0.33 | 0.02–3.92 | 0.38 | |
| 50–75 | 2.65 | 0.51–13.65 | 0.24 | |
| 75–100 | 9.37 | 1.7–51.63 | 0.01 |
CI, confidence interval; DM, diabetes mellitus; ESKD, end-stage kidney disease; HbA1c, hemoglobin A1c; HR, hazard ratio; UPCR, urine protein to creatinine ratio.
The global P value for the Cox proportionality of the model was 0.68. The best fit model is shown.