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TMA must be suspected with the triad of anemia, thrombocytopenia and target organ injury.
| TMA characters | Description |
|---|---|
| Microangiopathic hemolytic anemia | Anemia, decreased haptoglobin, elevated lactate dehydrogenase, schistocytes on peripheral blood smear. |
| Thrombocytopenia | Platelets <150,000 or 25% decline from baseline. |
| Target organ injury | Azotemia, hematuria, proteinuria or elevated liver enzymes or elevated amylase and lipase. |
TMA: thrombotic microangiopathy.
