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. 2021 Apr 10;17(6):1555–1564. doi: 10.7150/ijbs.59191

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Trichostatin A binds to the surface groove of SARS-CoV-2 M^pro with high stability. (A) Trichostatin A is predicted to be embedded in the M^pro catalytic groove with good shape complementarity. (B) The cartoon and stick representation of binding mode of trichostatin A: the hydrogen bonds between trichostatin A and LEU-141 or HIS-163 were marked by yellow dashed lines. The C-S bond between trichostatin A and CYS-145 was also indicated (arrow). (C) Illustration of the covalent reaction between trichostatin A and CYS-145 thiol.