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. 2021 Feb 2;50(2):295–306. doi: 10.1007/s00249-021-01501-z

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© The Author(s) 2021

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Fig. 2 — Protein-dependent mitochondrial inner membrane morphology. The schematic illustration of a part of a mitochondrion shows two major complexes (MICOS and F₁F_O ATP synthase) of the inner membrane (IM) that have been identified to directly affect cristae membrane (CM) formation. While the mitochondrial outer membrane (MOM) is relatively smooth, the MIM shows two morphological distinct subdomains: inner boundary membrane (IBM) and CM that are connected by cristae junction (CJ). Intermembrane space (IMS)